Antibacterial Effect of Berberrubine on the<i>Salmonella typhimurium</i>Type III Secretion System-Reference-Cited by-同舟云学术

Antibacterial Effect of Berberrubine on theSalmonella typhimuriumType III Secretion System

Published:2023-09 Issue:9 Volume:18 Page:
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Choi Won-Sik¹,Lee Tae-Hun¹,Son Se-Jin¹,Park Yeo Reum¹,Lee Tae-Young²,Javed Ahsan³,Choe Deokyeong³^ORCID,Kim Solomon L⁴,Kim Sung Uk⁵⁶,Lee Sang-Han³⁷^ORCID

Affiliation:

1. Research Institute, JeonjinBio Co., Ltd, Daegu, The Republic of Korea

2. Division of Emerging Infectious Disease & Vector Research, Center for Infectious Diseases Research, Osong, The Republic of Korea

3. Department of Food Science and Biotechnology, Kyungpook National University, Daegu, The Republic of Korea

4. California Northstate University College of Medicine, Elk Grove, CA, USA

5. Industrial Biomaterials Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, The Republic of Korea

6. Department of Food Science and Engineering, Seowon University, Cheongju, The Republic of Korea

7. Food & Bio-Industry Research Institute, Inner Beauty/Antiaging Center, Kyungpook National University, Daegu, The Republic of Korea

Abstract

The increasing antimicrobial drug resistance of Salmonella typhimurium has been a major public health problem in many countries. The type III secretion system (TTSS) of S typhimurium is an attractive target for the development of new antibiotics against this bacterium. In this study, we determined whether berberrubine derived from Berberis vulgaris could inhibit TTSS expression in S typhimurium . Berberrubine inhibited TTSS expression at a concentration of 60.9 µM. Additionally, TTSS-related mRNA expression of sipA, sipB, sopA, and sopD was downregulated in the presence of berberrubine. Collectively, we anticipate that berberrubine can be a useful tool to prevent the risks of infections caused by pathogenic bacteria.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X231189077

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