The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals-Reference-Cited by-同舟云学术

The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals

Published:2020-12-15 Issue:1 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Grillová Linda¹,Musilová Jana¹,Janečková Klára¹,Pospíšilová Petra¹,Kuklová Ivana²,Woznicová Vladana³,Zákoucká Hana⁴,Šmajs David¹^ORCID

Affiliation:

1. Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic

2. Department of Dermatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic

3. Department of Medical Microbiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic

4. National Reference Laboratory for Diagnostics of Syphilis, The National Institute for Public Health, Prague, Czech Republic

Abstract

Syphilis is a bacterial infection caused by Treponema pallidum subsp. pallidum . Infection with T. pallidum subsp. pallidum and its dissemination lead to the synthesis of proinflammatory cytokines triggered by the interaction of bacterial lipoproteins with Toll-like receptor 2 (TLR2). TLR2 contains several nonsynonymous single-nucleotide polymorphisms that may impact the activation of its signaling cascade and alter the responsiveness to, or the course of, various infectious diseases, including those caused by pathogenic spirochetes.

Funder

Ministry of Health of the Czech Republic

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00503-20

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