Toll-Like Receptor 2 Arg677Trp Polymorphism Is Associated with Susceptibility to Tuberculosis in Tunisian Patients-Reference-Cited by-同舟云学术

Toll-Like Receptor 2 Arg677Trp Polymorphism Is Associated with Susceptibility to Tuberculosis in Tunisian Patients

Published:2004-05 Issue:3 Volume:11 Page:625-626
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Ben-Ali Meriem¹,Barbouche Mohamed-Ridha¹,Bousnina Soufia²,Chabbou Abdellatif²,Dellagi Koussay¹

Affiliation:

1. Laboratoire d'Immunologie, de Vaccinologie et de Génétique Moléculaire, Institut Pasteur de Tunis, Tunis

2. Service de Pneumo-phtysiologie, Centre Hospitalo-Universitaire Abderrahmen Mami, Ariana, Tunisia

Abstract

ABSTRACT Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacteria. Herein, we report that the frequency of a human TLR2 Arg677Trp polymorphism (C2029T nucleotide substitution) in tuberculosis patients in Tunisia is significantly higher than in healthy controls ( P < 0.0001). This finding suggests that this polymorphism could be a risk factor for tuberculosis.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CDLI.11.3.625-626.2004

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