Expanding the Enzyme Repertoire for Sugar Nucleotide Epimerization: the CDP-Tyvelose 2-Epimerase from Thermodesulfatator atlanticus for Glucose/Mannose Interconversion-Reference-Cited by-同舟云学术

Expanding the Enzyme Repertoire for Sugar Nucleotide Epimerization: the CDP-Tyvelose 2-Epimerase from Thermodesulfatator atlanticus for Glucose/Mannose Interconversion

Published:2021-01-29 Issue:4 Volume:87 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Rapp Christian¹,van Overtveldt Stevie²,Beerens Koen²,Weber Hansjörg³,Desmet Tom²⁴,Nidetzky Bernd¹⁴^ORCID

Affiliation:

1. Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, Graz, Austria

2. Centre for Synthetic Biology, Department of Biotechnology, Ghent University, Ghent, Belgium

3. Institute of Organic Chemistry, Graz University of Technology, NAWI Graz, Graz, Austria

4. Austrian Centre of Industrial Biotechnology (acib), Graz, Austria

Abstract

Epimerases of the sugar nucleotide-modifying class of enzymes have attracted considerable interest in carbohydrate (bio)chemistry for the mechanistic challenges and the opportunities for synthesis involved in the reactions catalyzed. The discovery of new epimerases with an expanded scope of sugar nucleotide substrates used is important to promote mechanistic inquiry and can facilitate the development of new enzyme applications.

Funder

Fonds Wetenschappelijk Onderzoek

Austrian Science Fund

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.02131-20

Reference64 articles.

1. The “epimerring” highlights the potential of carbohydrate epimerases for rare sugar production

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