RNA III Inhibiting Peptide Inhibits In Vivo Biofilm Formation by Drug-Resistant Staphylococcus aureus

Author:

Giacometti Andrea1,Cirioni Oscar1,Gov Yael2,Ghiselli Roberto3,Del Prete Maria Simona1,Mocchegiani Federico3,Saba Vittorio3,Orlando Fiorenza4,Scalise Giorgio1,Balaban Naomi2,Dell'Acqua Giorgio5

Affiliation:

1. Institute of Infectious Diseases and Public Health

2. Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

3. Department of General Surgery, Istituto Nazionale Riposo e Cura Anziani, Istituto di Ricovero e Cura a Carattere Scientifico, University of Ancona

4. Biotechnology Centre, Research Department, Istituto Nazionale Riposo e Cura Anziani, Istituto di Ricovero e Cura a Carattere Scientifico, Ancona, Italy

5. Laboratoires Biologiques Arval SA, Conthey, Switzerland

Abstract

ABSTRACT Staphylococcus aureus is a prevalent cause of bacterial infections associated with indwelling medical devices. RNA III inhibiting peptide (RIP) is known to inhibit S. aureus pathogenesis by disrupting quorum-sensing mechanisms. RIP was tested in the present study for its ability to inhibit S. aureus biofilm formation in a rat Dacron graft model. The activity of RIP was synergistic with those of antibiotics for the complete prevention of drug-resistant S. aureus infections.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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