Production of Apx toxins by field strains of Actinobacillus pleuropneumoniae and Actinobacillus suis

Author:

Kamp E M1,Vermeulen T M1,Smits M A1,Haagsma J1

Affiliation:

1. Department of Bacteriology, Central Veterinary Institute, Lelystad, The Netherlands.

Abstract

The three Apx toxins of Actinobacillus pleuropneumoniae have potential value for use in vaccines and diagnostic tests which will be species specific instead of serotype specific, provided that the Apx toxins are species specific and all field strains produce these toxins. We examined 114 A. pleuropneumoniae field strains and found that they secreted either ApxI, ApxII, ApxI and ApxII, or ApxII and ApxIII and secreted no other cytolytic activities. However, proteins similar to ApxI and ApxII were also produced by Actinobacillus suis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference23 articles.

1. Capsular polysaccharide antigens for detection of serotype-specific antibodies to Actinobacillus pleuropneumoniae;Bosse J. T.;Can. J. Vet. Res.,1990

2. Molecular characterization of an RTX toxin determinant from Actinobacillus suis;Burrows L. L.;Infect. Immun.,1992

3. Cowan S. T. and K. J. Steel. 1974. Cowan and Steel's manual for the identification of medical bacteria 2nd ed. Cambridge University Press Cambridge.

4. Humoral antibody response and protective immunity in swine following immunization with the 104-kilodalton hemolysin of Actinobacillus pleuropneumoniae;Devenish J.;Infect. Immun.,1990

5. Prevalence of seroreactors to the 104-kilodalton hemolysin of Actinobacillus pleuropneumoniae in swine herds;Devenish J.;J. Clin. Microbiol.,1990

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