Antiviral CD19<sup>+</sup>CD27<sup>+</sup>Memory B Cells Are Associated with Protection from Recurrent Asymptomatic Ocular Herpesvirus Infection-Reference-Cited by-同舟云学术

Antiviral CD19⁺CD27⁺Memory B Cells Are Associated with Protection from Recurrent Asymptomatic Ocular Herpesvirus Infection

Published:2022-03-09 Issue:5 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Dhanushkodi Nisha R.¹,Prakash Swayam¹,Srivastava Ruchi¹,Coulon Pierre-Gregoire A.¹,Arellano Danielle¹,Kapadia Rayomand V.¹,Fahim Raian¹,Suzer Berfin¹,Jamal Leila¹,Vahed Hawa²,BenMohamed Lbachir¹³²⁴^ORCID

Affiliation:

1. Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, California, USA

2. Department of Vaccines and Immunotherapies, TechImmune, LLC, University Lab Partners, Irvine, California, USA

3. Department of Molecular Biology & Biochemistry, University Lab Partners, Irvine, California, USA

4. Institute for Immunology, University of California Irvine, School of Medicine, Irvine, California, USA

Abstract

Reactivation of herpes simplex virus 1 (HSV-1) from latently infected neurons of the trigeminal ganglia (TG) leads to blinding recurrent herpetic disease in symptomatic (SYMP) individuals. Although the role of T cells in herpes immunity against blinding recurrent herpetic disease is heavily explored, the role of B cells is less investigated.

Funder

HHS | NIH | National Eye Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.02057-21

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