Costimulation of Naive CD8+ Lymphocytes Induces CD4 Expression and Allows Human Immunodeficiency Virus Type 1 Infection-Reference-Cited by-同舟云学术

Costimulation of Naive CD8+ Lymphocytes Induces CD4 Expression and Allows Human Immunodeficiency Virus Type 1 Infection

Published:1998-11-01 Issue:11 Volume:72 Page:9054-9060
ISSN:1098-5514
Container-title:Journal of Virology
language:en
Short-container-title:J. Virol.

Author:

Kitchen Scott G.¹,Korin Yael D.²,Roth Michael D.³,Landay Alan⁴,Zack Jerome A.¹⁵

Affiliation:

1. Division of Hematology-Oncology1 and

2. Department of Pathology & Laboratory Medicine,2 and

3. Division of Pulmonary & Critical Care,3 Department of Medicine,

4. Department of Immunology & Microbiology, Rush Presbyterian-St. Luke’s Medical Center, Chicago, Illinois 606124

5. Department of Microbiology & Molecular Genetics,5 UCLA School of Medicine, Los Angeles, California 90095, and

Abstract

ABSTRACT Human immunodeficiency virus type 1 (HIV-1) infection requires cell surface expression of CD4. Costimulation of CD8+/CD4− T lymphocytes by anti-CD3 and anti-CD28 antibodies or by allogeneic dendritic cells induced expression of CD4 and rendered these CD8 cells susceptible to HIV-1 infection. Naive CD45RA+ cells responded with greater expression of CD4 than did CD45RO+ cells. CD8+lymphocytes derived from fetal or newborn sources exhibited a greater tendency to express CD4, consistent with their naive states. This mechanism of infection suggests HIV-induced perturbation of the CD8 arm of the immune response and could explain the generally rapid disease progression seen in HIV-infected children.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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