Population Pharmacokinetics of Intravenous and Oral Acyclovir and Oral Valacyclovir in Pediatric Population To Optimize Dosing Regimens-Reference-Cited by-同舟云学术

Population Pharmacokinetics of Intravenous and Oral Acyclovir and Oral Valacyclovir in Pediatric Population To Optimize Dosing Regimens

Published:2020-11-17 Issue:12 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Abdalla S.¹,Briand C.²,Oualha M.¹³,Bendavid M.³,Béranger A.¹³,Benaboud S.¹⁴,Tréluyer J.-M.¹⁴⁵⁶,Zheng Y.¹⁴,Capito C.⁷,Demir Z.⁸,Foissac F.¹⁵⁶,Winter S.²,Gana I.¹⁴,Boujaafar S.¹⁴,Bouazza N.¹⁵⁶,Hirt D.¹⁴⁹^ORCID

Affiliation:

1. EA7323, Evaluation des Thérapeutiques et Pharmacologie Périnatale et Pédiatrique, Université de Paris, Paris, France

2. Service d’Hématologie, Immunologie et Rhumatologie Pédiatrique, Hôpital Necker-Enfants Malades, Paris, France

3. Service de Réanimation et Surveillance Continue Médico-Chirurgicales Pédiatriques, Hôpital Necker-Enfants Malades, Paris, France

4. Service de Pharmacologie Clinique, AP-HP, Hôpital Cochin, Paris, France

5. Unite de Recherche Clinique Paris Descartes Necker Cochin, AP-HP, Paris, France

6. CIC-1419 Inserm, Cochin-Necker, Paris, France

7. Service de Chirurgie Viscérale et Urologique Pédiatriques, Hôpital Necker-Enfants Malades, Paris, France

8. Service de Gastro-Entérologie, Hépatologie et Nutrition Pédiatriques, Hôpital Necker-Enfants Malades, Paris, France

9. INSERM, U1018, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France

Abstract

Acyclovir is an antiviral currently used for the prevention and treatment of herpes simplex virus (HSV) and varicella-zoster virus (VZV) infections. This study aimed to characterize the pharmacokinetics (PK) of acyclovir and its oral prodrug valacyclovir to optimize dosing in children. Children receiving acyclovir or valacyclovir were included in this study. PK were described using nonlinear mixed-effect modeling. Dosing simulations were used to obtain trough concentrations above a 50% inhibitory concentration for HSV or VZV (0.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01426-20

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