Disk diffusion susceptibility testing for LY163892 (KT-3777), a new orally administered 1-carbacephem

Author:

Jones R N1,Barry A L1

Affiliation:

1. Clinical Microbiology Institute, Tualatin, Oregon 97062.

Abstract

LY163892, a new orally administered 1-carbacephem, was found to have a spectrum of antimicrobial activity very similar to that of cefaclor. Diffusion tests with 30-micrograms LY163892 disks produced acceptable interpretive error rates with greater than or equal to 22 mm as the susceptibility zone diameter. This was required to reduce potential false-susceptibility results, particularly among Enterobacter spp. and Providencia stuartii: both species included strains that produce beta-lactamases capable of hydrolyzing Ly163892. Preliminary recommendations for LY163892 disk tests are presented, but the continued use of the 30-micrograms cephalothin "class representative" disk might be the best procedure to minimize LY163892 interpretive errors for clinical trials. A separate LY163892 disk for testing Haemophilus influenzae strains should be seriously considered.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference13 articles.

1. Cefuroxime, in vitro comparison to six other cephalosporins;Barry A. L.;Proc. R. Soc. Med.,1977

2. Stability and blood level determinations of cefaclor, a new oral cephalosporin antibiotic;Foglesong M. A.;Antimicrob. Agents Chemother.,1978

3. Cefixime disk susceptibility test criteria;Fuchs P. C.;J. Clin. Microbiol.,1986

4. Preliminary antimicrobial susceptibility interpretive criteria for cefetamet (Ro 15-8074) and cefteram (Ro 19-5247) disk tests;Jones R. N.;J. Clin. Microbiol.,1987

5. Beta-lactamase hydrolysis and inhibition studies of the new 1-carbacephem, LY163892;Jones R. N.;Eur. J. Clin. Microbiol.,1987

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