Different Responses of Macrophages to Smooth and Rough Brucella spp.: Relationship to Virulence-Reference-Cited by-同舟云学术

Different Responses of Macrophages to Smooth and Rough Brucella spp.: Relationship to Virulence

Published:2004-04 Issue:4 Volume:72 Page:2429-2433
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Jiménez de Bagüés María P.¹,Terraza Annie²,Gross Antoine²,Dornand Jacques²

Affiliation:

1. Unidad de Sanidad Animal, Servicio de Investigación Agroalimentaria, Diputación General de Aragón, 50080 Zaragoza, Spain

2. INSERM U431, Université de Montpellier II, 34095 Montpellier, France

Abstract

ABSTRACT By comparing smooth wild-type Brucella strains to their rough mutants, we show that the lipopolysaccharide (LPS) O side chain of pathogenic Brucella has a dramatic impact on macrophage activation. It favors the development of virulent Brucella by preventing the synthesis of immune mediators, important for host defense. We conclude that this O chain property is firmly linked to Brucella virulence.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.72.4.2429-2433.2004

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