Affiliation:
1. Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Shenyang Agricultural University, 110866, Shenyang, China
Abstract
Abstract::
Brucella is an intracellular bacterial pathogen capable of long-term persistence in the host,
resulting in chronic infections in livestock and wildlife. The type IV secretion system (T4SS) is an important
virulence factor of Brucella and is composed of 12 protein complexes encoded by the VirB operon.
T4SS exerts its function through its secreted 15 effector proteins. The effector proteins act on important
signaling pathways in host cells, inducing host immune responses and promoting the survival and
replication of Brucella in host cells to promote persistent infection. In this article, we describe the intracellular
circulation of Brucella-infected cells and survey the role of Brucella VirB T4SS in regulating
inflammatory responses and suppressing host immune responses during infection. In addition, the important
mechanisms of these 15 effector proteins in resisting the host immune response during Brucella
infection are elucidated. For example, VceC and VceA assist in achieving sustained survival of Brucella
in host cells by affecting autophagy and apoptosis. BtpB, together with BtpA, controls the activation of
dendritic cells during infection, induces inflammatory responses, and controls host immunity. This article
reviews the effector proteins secreted by Brucella T4SS and their involvement in immune responses,
which can provide a reliable theoretical basis for the subsequent mechanism of hijacking the host cell
signaling pathway by bacteria and contribute to the development of better vaccines to effectively treat
Brucella bacterial infection.
Funder
Science & Technology Program of Liaoning Province
State Key Program of the National Natural Science Foundation of China
China Postdoctoral Science Foundation
NSFC International (regional) cooperation and exchange program
Key Program of Inner Mongolia
Publisher
Bentham Science Publishers Ltd.
Subject
General Medicine,Medicine (miscellaneous)
Cited by
2 articles.
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