Identification of Human Herpesvirus 8-Specific Cytotoxic T-Cell Responses-Reference-Cited by-同舟云学术

Identification of Human Herpesvirus 8-Specific Cytotoxic T-Cell Responses

Published:1999-07 Issue:7 Volume:73 Page:6136-6140
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Osman Mohamed¹²,Kubo Toru¹,Gill Jasjit³,Neipel Frank⁴,Becker Marion⁵,Smith Geoffrey⁵,Weiss Robin²,Gazzard Brian³,Boshoff Chris²,Gotch Frances¹

Affiliation:

1. Department of Immunology,2 Chelsea and Westminster Hospital, Imperial College School of Medicine, and

2. Departments of Oncology and Molecular Pathology, Royal Free and University College Medical School, University College London,1 London, and

3. Department of Genitourinary Medicine3 and

4. Institut für Klinische und Molekulare Virologie, Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany,4 and

5. Dunn School of Pathology, University of Oxford, Oxford,5 United Kingdom

Abstract

ABSTRACT Human herpesvirus 8 (HHV-8) (or Kaposi’s sarcoma-associated herpesvirus) is implicated in the etiopathogenesis of Kaposi’s sarcoma (KS) and certain lymphoproliferations. The introduction of more effective therapies to treat human immunodeficiency virus infection has led to a decline in the incidence of KS and also in the resolution of KS in those already affected. This suggests that cellular immune responses including cytotoxic T lymphocytes (CTLs) could play a vital role in the control of HHV-8 infection and in KS pathogenesis. Here we elucidate HLA class I-restricted, HHV-8-specific cellular immune responses that could be important in the control of HHV-8 infection and subsequent tumor development. We show the presence of CTLs against HHV-8 latent (K12), lytic (K8.1), and highly variable (K1) proteins in infected individuals.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.73.7.6136-6140.1999

Reference35 articles.

1. Establishment of a KSHV positive cell line (BCP-1) from peripheral blood and characterizing its growth in vivo;Boshoff C.;Blood,1998

2. Kaposi’s sarcoma-associated herpesvirus;Boshoff C.;Advances in cancer research,1998

3. Host range and cytopathogenicity of the highly attenuated MVA strain of vaccinia virus: propagation and generation of recombinant viruses in non-human mammalian cell line;Carroll M.;Virology,1997

4. Lymphoproliferations associated with KSHV;Cesarman E.;Seminars in cancer biology,1999

5. Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques

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