Cyclo-( l -Phe- l -Pro), a Quorum-Sensing Signal of Vibrio vulnificus, Induces Expression of Hydroperoxidase through a ToxR-LeuO-HU-RpoS Signaling Pathway To Confer Resistance against Oxidative Stress-Reference-Cited by-同舟云学术

Cyclo-( l -Phe- l -Pro), a Quorum-Sensing Signal of Vibrio vulnificus, Induces Expression of Hydroperoxidase through a ToxR-LeuO-HU-RpoS Signaling Pathway To Confer Resistance against Oxidative Stress

Published:2018-09 Issue:9 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Kim In Hwang¹²,Kim So-Yeon¹,Park Na-Young¹,Wen Yancheng¹,Lee Keun-Woo¹,Yoon So-Young¹,Jie Haneul¹,Lee Kyu-Ho¹,Kim Kun-Soo¹

Affiliation:

1. Department of Life Sciences, Sogang University, Seoul, South Korea

2. Research Institute for Basic Science, Sogang University, Seoul, South Korea

Abstract

Vibrio vulnificus , an opportunistic human pathogen, produces cyclo-( l -Phe- l -Pro) (cFP), which serves as a signaling molecule controlling the ToxR-dependent expression of innate bacterial genes, and also as a virulence factor eliciting pathogenic effects on human cells by enhancing intracellular reactive oxygen species levels. We found that cFP facilitated the protection of V. vulnificus against hydrogen peroxide.

Funder

National Research Foundation of Korea

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00932-17

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