Affiliation:
1. National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA.
Abstract
Intestinal microfloras from human, rat, mouse, and monkey fecal samples and 14 pure cultures of anaerobic bacteria representative of those found in the human gastrointestinal tract metabolized the triphenylmethane dye malachite green to leucomalachite green. The reduction of malachite green to the leuco derivative suggests that intestinal microflora could play an important role in the metabolic activation of the triphenylmethane dye to a potential carcinogen.
Publisher
American Society for Microbiology
Subject
Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology
Reference22 articles.
1. Malachite green: a review;Alderman D. J.;J. Fish Dis.,1985
2. Malachite green: a pharmacokinetic study in rainbow trout, Oncorhynchus mykiss (Walbaum);Alderman D. J.;J. Fish Dis.,1993
3. Fate and distribution of some drugs used in aquaculture;Allen J. L.;Vet. Hum. Toxicol.,1986
4. Determination of malachite green residues in the eggs, fry, and adult muscle tissue of rainbow trout (Oncorhynchus mykiss);Allen J. L.;J. Assoc. Off. Anal. Chem. Int.,1994
5. Role of gastrointestinal mucosa and microflora in the bioactivation of dietary and environmental mutagens or carcinogens;Chadwick R. W.;Drug Metab. Rev.,1992
Cited by
82 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献