Reduction of malachite green to leucomalachite green by intestinal bacteria

Author:

Henderson A L1,Schmitt T C1,Heinze T M1,Cerniglia C E1

Affiliation:

1. National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA.

Abstract

Intestinal microfloras from human, rat, mouse, and monkey fecal samples and 14 pure cultures of anaerobic bacteria representative of those found in the human gastrointestinal tract metabolized the triphenylmethane dye malachite green to leucomalachite green. The reduction of malachite green to the leuco derivative suggests that intestinal microflora could play an important role in the metabolic activation of the triphenylmethane dye to a potential carcinogen.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Reference22 articles.

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4. Determination of malachite green residues in the eggs, fry, and adult muscle tissue of rainbow trout (Oncorhynchus mykiss);Allen J. L.;J. Assoc. Off. Anal. Chem. Int.,1994

5. Role of gastrointestinal mucosa and microflora in the bioactivation of dietary and environmental mutagens or carcinogens;Chadwick R. W.;Drug Metab. Rev.,1992

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