Molecular Characterization of Isoniazid Resistance in Mycobacterium tuberculosis : Identification of a Novel Mutation in inhA-Reference-Cited by-同舟云学术

Molecular Characterization of Isoniazid Resistance in Mycobacterium tuberculosis : Identification of a Novel Mutation in inhA

Published:2006-03 Issue:3 Volume:50 Page:1075-1078
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Leung E. T. Y.¹,Ho P. L.¹,Yuen K. Y.¹,Woo W. L.¹,Lam T. H.¹,Kao R. Y.¹,Seto W. H.¹,Yam W. C.¹

Affiliation:

1. Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China

Abstract

ABSTRACT Multiplex allele-specific PCRs detecting katG codon 315 and mabA (bp −15) mutations could specifically identify 77.5% of isoniazid-resistant Mycobacterium tuberculosis strains in the South China region. One clinical isolate harboring InhA Ile194Thr was characterized to show strong association with isoniazid resistance in Mycobacterium tuberculosis .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.50.3.1075-1078.2006

Reference22 articles.

1. Molecular Analysis of Isoniazid-Resistant Mycobacterium tuberculosis Isolates from England and Wales Reveals the Phylogenetic Significance of the ahpC −46A Polymorphism

2. Banerjee, A., E. Dubnau, A. Quemard, V. Balasubramanian, K. S. Um, T. Wilson, D. Collins, G. de Lisle, and W. R. Jacobs, Jr. 1994. inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science263:227-230.

3. Basso, L. A., R. Zheng, J. M. Musser, W. R. Jacobs, Jr., and J. S. Blanchard. 1998. Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates. J. Infect. Dis.178:769-775.

4. In Vitro Inhibition of the Mycobacterium tuberculosis β-Ketoacyl-Acyl Carrier Protein Reductase MabA by Isoniazid

5. Gomes-Guimaraes, B., H. Souchon, N. Honore, B. Saint-Joanis, R. Brosch, W. Shepard, S. T. Cole, and P. M. Alzari. 2005. Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress. J. Biol. Chem.280:25735-25742.

Cited by 40 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. In Silico Antibacterial Activity of Polyacetilene Derivatives Against Mycobacterium tuberculosis and In-Vitro Antioxidant Properties from Ethanol Extraction of Blackjack (Bidens pilosa L.);Jurnal Kimia Sains dan Aplikasi;2024-05-02

2. Whole-genome sequencing of Mycobacterium tuberculosis for prediction of drug resistance;Epidemiology and Infection;2022

3. Highly transmitted M. tuberculosis strains are more likely to evolve MDR/XDR and cause outbreaks, but what makes them highly transmitted?;Tuberculosis;2021-07

4. Comprehensive review on mechanism of action, resistance and evolution of antimycobacterial drugs;Life Sciences;2021-06

5. Drug resistant Tuberculosis: A review;Comparative Immunology, Microbiology and Infectious Diseases;2021-02