Protective Role of Neutrophils in Mice Experimentally Infected with Rhodococcus equi-Reference-Cited by-同舟云学术

Protective Role of Neutrophils in Mice Experimentally Infected with Rhodococcus equi

Published:2005-10 Issue:10 Volume:73 Page:7040-7042
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Martens Ronald J.¹,Cohen Noah D.¹,Jones Samuel L.²,Moore Thomas A.³,Edwards John F.⁴

Affiliation:

1. Equine Infectious Disease Laboratory, Department of Large Animal Clinical Sciences

2. Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina

3. Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan

4. Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas

Abstract

ABSTRACT Neutrophils are important in controlling early infections with the intracellular bacterium Rhodococcus equi . Antineutrophil monoclonal antibody (RB6-8C5)-induced neutrophil deficiency during the first week after experimental infection of mice with R. equi resulted in more severe disease and significantly increased tissue concentrations of R. equi.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.73.10.7040-7042.2005

Reference15 articles.

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2. Chaffin, M. K., N. D. Cohen, R. J. Martens, R. F. Edwards, M. Nevill, and R. Smith III. 2004. Hematologic and immunophenotypic factors associated with development of Rhodococcus equi pneumonia of foals at equine breeding farms with endemic infection. Vet. Immunol. Immunopathol.100:33-48.

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4. Darrah, P., M. C. G. Monaco, S. Jain, M. K. Hondalus, D. T. Golenbock, and D. M. Mosser. 2004. Innate immune responses to Rhodococcus equi. J. Immunol.173:1914-1924.

5. Denkers, E. Y., L. Del Rio, and B. Soumaya. 2003. Neutrophil production of IL-12 and other cytokines during microbial infection. Chem. Immunol. Allergy83:95-114.

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