Abstract
Five lots of phase 1 Q fever antigen suitable for use as vaccine were prepared utilizing the Freon-brushite method of antigen purification. Antigen concentration levels were initially adjusted turbidimetrically and later confirmed by antibody response in guinea pigs. Data showed that all lots were essentially identical in purity and antigenicity.
Publisher
American Society for Microbiology
Subject
Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology
Reference16 articles.
1. Method for the production of a purified dry Q fever vaccine;Berman S.;J. Bacteriol.,1961
2. Purification of large quantities of Coxiella burnetii rickettsia by density gradient zonal centrifugation;Canonico P. G.;Appl. Microbiol.,1972
3. Preparation of purified suspensions of Coxiella burnetii by Genetron extraction followed by continuous-flow ultracentrifugation;Dubois D. R.;Appl. Microbiol.,1972
4. Fiset P. 1967. Vaccination against Q fever p. 528-531. In Proceedings of First International Conference on Vaccines Against Viral and Rickettsial Diseases of Man PAHO science publication no. 147. Pan American Health Organization Washington D.C.
5. A microagglutination technique for detection and measurement of rickettsial antibodies;Fiset P.;Acta Virol.,1969
Cited by
12 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献