Population Pharmacokinetics and Target Attainment of Cefepime in Critically Ill Patients and Guidance for Initial Dosing-Reference-Cited by-同舟云学术

Population Pharmacokinetics and Target Attainment of Cefepime in Critically Ill Patients and Guidance for Initial Dosing

Published:2020-08-20 Issue:9 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Al-Shaer Mohammad H.¹²^ORCID,Neely Michael N.³,Liu Jiajun⁴⁵⁶^ORCID,Cherabuddi Kartikeya⁷,Venugopalan Veena²,Rhodes Nathaniel J.⁴⁵⁶^ORCID,Klinker Kenneth²^ORCID,Scheetz Marc H.⁴⁵⁶^ORCID,Peloquin Charles A.¹²^ORCID

Affiliation:

1. Infectious Disease Pharmacokinetics Laboratory, Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA

2. Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, Florida, USA

3. Children's Hospital of Los Angeles, Laboratory of Applied Pharmacokinetics and Bioinformatics, Los Angeles, California, USA

4. Midwestern University Chicago College of Pharmacy, Downers Grove, Illinois, USA

5. Northwestern Memorial Hospital, Chicago, Illinois, USA

6. Pharmacometrics Center of Excellence, Midwestern University Chicago College of Pharmacy, Downers Grove, Illinois, USA

7. Division of Infectious Diseases, College of Medicine, University of Florida, Gainesville, Florida, USA

Abstract

Cefepime is commonly used in the intensive care unit (ICU) to treat bacterial infections. The time during which the free cefepime concentration is above the MIC ( f T >MIC ) should be optimized to increase the efficacy of the regimen. We aim to optimize the exposure of cefepime in ICU patients by using population pharmacokinetic (PK) modeling and simulations. Two data sets were included in this study. The first was a prospective study of pediatric patients who received cefepime at 50 mg/kg of body weight and had extensive PK sampling.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00745-20

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