Suppression of Murine Lymphocyte Mitogen Responses by Exopolysaccharide from Capnocytophaga ochracea

Author:

Bolton Ronald W.1,Dyer John K.1

Affiliation:

1. Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, Nebraska 68583-0740

Abstract

An extracellular polysaccharide was purified from culture supernatants of Capnocytophaga ochracea 25, a gram-negative bacillus associated with human periodontal disease. The extracellular polysaccharide suppressed in vitro mitogenic responses of murine splenic lymphocytes to concanavalin A and lipopolysaccharide. This suppression wad dose dependent, persisted up to 120 h, and was not caused by direct toxicity of the extracellular polysaccharide.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference18 articles.

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4. The modulating effect of cholera enterotoxin on the immune response;Chisari F. V.;J. Immunol.,1974

5. The primary immune response in mice. I. The enhancement and suppression of hemolysin production by bacterial endotoxin;Franzl R. W.;J. Exp. Med.,1968

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