Characterization of FosL1, a Plasmid-Encoded Fosfomycin Resistance Protein Identified in Escherichia coli-Reference-Cited by-同舟云学术

Characterization of FosL1, a Plasmid-Encoded Fosfomycin Resistance Protein Identified in Escherichia coli

Published:2020-03-24 Issue:4 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kieffer Nicolas¹,Poirel Laurent¹²³,Descombes Marie-Christine⁴,Nordmann Patrice¹²³⁵

Affiliation:

1. Medical and Molecular Microbiology, Section of Medicine, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland

2. INSERM European Unit (IAME, France), University of Fribourg, Fribourg, Switzerland

3. Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Fribourg, Switzerland

4. Laboratoire Proxilis, Meyrin, Switzerland

5. Institute for Microbiology, University of Lausanne and University Hospital Centre, Lausanne, Switzerland

Abstract

Fosfomycin is gaining renewed interest for treating urinary tract infections. Monitoring fosfomycin resistance is therefore important in order to detect the emergence of novel resistance mechanisms. Here, we used the Rapid Fosfomycin NP test to screen a collection of extended-spectrum-β-lactamase-producing Escherichia coli isolates from Switzerland and found a fosfomycin-resistant isolate in which a novel plasmid-mediated fosfomycin resistance gene, named fosL1 , was identified.

Funder

University of Fribourg

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02042-19

Reference33 articles.

1. Fosfomycin: Mechanism and Resistance

2. Fosfomycin for treatment of multidrug-resistant pathogens causing urinary tract infection: A real-world perspective and review of the literature

3. Gene Cassettes Potentially Encoding Fosfomycin Resistance Determinants