Clinical Relevance of Topical Antibiotic Use in Coselecting for Multidrug-Resistant Staphylococcus aureus: Insights from In Vitro and Ex Vivo Models

Author:

Nong Yi1ORCID,Taiaroa George1,Pasricha Shivani1,Guérillot Romain1,Monk Ian R.1,Baines Sarah L.1ORCID,Carter Glen P.12,Howden Benjamin P.132,Williamson Deborah A.134ORCID

Affiliation:

1. Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia

2. Doherty Applied Microbial Genomics, Doherty Institute, The University of Melbourne, Melbourne, Australia

3. Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology & Immunology, The University of Melbourne at The Doherty Institute for Infection and Immunity, Melbourne, Australia

4. Department of Microbiology, Royal Melbourne Hospital, Melbourne, Australia

Abstract

Topical antibiotic preparations, such as fusidic acid (FA) or mupirocin, are used in the prevention and treatment of superficial skin infections caused by staphylococci. Previous genomic epidemiology work has suggested an association between the widespread use of topical antibiotics and the emergence of methicillin-resistant Staphylococcus aureus in some settings.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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