Potent inhibition of hepatitis B virus production in vitro by modified pyrimidine nucleosides-Reference-Cited by-同舟云学术

Potent inhibition of hepatitis B virus production in vitro by modified pyrimidine nucleosides

Published:1990-10 Issue:10 Volume:34 Page:1986-1990
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Matthes E¹,Langen P¹,von Janta-Lipinski M¹,Will H¹,Schröder H C¹,Merz H¹,Weiler B E¹,Müller W E¹

Affiliation:

1. Zentralinstitut für Molekularbiologie, Akademie der Wissenschaften der Deutschen Demokratischen Republik, Berlin-Buch, German Democratic Republic.

Abstract

2',3'-Dideoxy-3'-fluorothymidine (FddThd), 2',3'-didehydro-2',3'- dideoxythymidine (ddeThd), and 3'-fluoro-5-methyl-deoxycytidine (FddMeCyt) are, in their triphosphate forms, selective inhibitors of human immunodeficiency virus type 1 reverse transcriptase. We report that 0.3 microM FddThd, FddMeCyt, or ddeThd as well as 3'-chloro-5-methyl-deoxycytidine (ClddMeCyt) or 3'-amino-5-methyl-deoxycytidine (AddMeCyt) almost completely blocked production of hepatitis B virus (HBV) particles by HBV DNA-transfected cell line 2.2.15 in vitro. Only at an at least 10-fold-higher concentration was a cytotoxic effect observed. These results indicate that FddThd, FddMeCyt, ClddMeCyt, AddMeCyt, and ddeThd are potent anti-HBV agents in vitro.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.34.10.1986

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