Selection of Bis-Indolyl Pyridines and Triphenylamines as New Inhibitors of SARS-CoV-2 Cellular Entry by Modulating the Spike Protein/ACE2 Interfaces-Reference-Cited by-同舟云学术

Selection of Bis-Indolyl Pyridines and Triphenylamines as New Inhibitors of SARS-CoV-2 Cellular Entry by Modulating the Spike Protein/ACE2 Interfaces

Published:2022-08-16 Issue:8 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lapaillerie Delphine¹²,Charlier Cathy³,Guyonnet-Dupérat Véronique⁴,Murigneux Emilie⁵,Fernandes Henrique S.⁶,Martins Fábio G.⁶,Magalhães Rita P.⁶,Vieira Tatiana F.⁶,Richetta Clémence⁷,Subra Frédéric⁷,Lebourgeois Samuel⁸,Charpentier Charlotte⁸,Descamps Diane⁸,Visseaux Benoît⁸^ORCID,Weigel Pierre³,Favereaux Alexandre⁹,Beauvineau Claire¹⁰,Buron Frédéric¹¹,Teulade-Fichou Marie-Paule¹⁰,Routier Sylvain¹¹,Gallois-Montbrun Sarah⁵,Meertens Laurent¹²,Delelis Olivier⁷²^ORCID,Sousa Sérgio F.⁶,Parissi Vincent¹²^ORCID

Affiliation:

1. Fundamental Microbiology and Pathogenicity Lab (MFP), UMR 5234 CNRS, University of Bordeaux, Bordeaux, France

2. Viral DNA Integration and Chromatin Dynamics Network (DyNAVir), Paris, France

3. Nantes Université, CNRS, US2B, UMR 6286, Nantes, France

4. Vect’UB, Vectorology Platform, INSERM US05–CNRS UMS 3427–TBM-Core, Université de Bordeaux, Bordeaux, France

5. Université de Paris, Institut Cochin, INSERM, CNRS UMR8104, Paris, France

6. UCIBIO/QUIMTE, BioSIM, Departamento de Medicina, Faculdade de Medicina, Universidade Do Porto, Porto, Portugal

7. LBPA, ENS Paris Saclay, Gif-sur-Yvette, France

8. Université de Paris, INSERM, IAME, UMR 1137, Service de Virologie, AP-HP, Hôpital Bichat-Claude Bernard, Paris, France

9. IINS, Bordeaux, France

10. Institut Curie Centre de Recherche, CMBC, CNRS UMR9187, INSERM U1196, Université Paris-Saclay, Orsay, France

11. Institut de Chimie Organique et Analytique, Université d’Orléans, CNRS UMR7311, Orléans, France

12. Hôpital Saint Louis, Paris, France

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the infectious agent that has caused the current coronavirus disease (COVID) pandemic. Viral infection relies on the viral S (spike) protein/cellular receptor ACE2 interaction.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00083-22

Reference23 articles.

1. Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

2. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

3. Expression of ACE2 in Human Neurons Supports the Neuro-Invasive Potential of COVID-19 Virus

4. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis

5. TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells

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