Polyomavirus Shedding in the Stool of Healthy Adults-Reference-Cited by-同舟云学术

Polyomavirus Shedding in the Stool of Healthy Adults

Published:2009-08 Issue:8 Volume:47 Page:2388-2391
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Vanchiere John A.¹²,Abudayyeh Suhaib³,Copeland Christina M.²,Lu Lee B.³,Graham David Y.³⁴,Butel Janet S.⁴

Affiliation:

1. Department of Pediatrics, Section of Infectious Diseases

2. Department of Pediatrics, Section of Infectious Diseases, Louisiana State University Health Sciences Center, Shreveport, Louisiana

3. Department of Medicine

4. Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas

Abstract

ABSTRACT We recently reported the frequent detection of polyomaviruses (BK virus [BKV] or simian virus 40 [SV40]) in 46% of stool samples from hospitalized children. In order to determine if adults exhibit fecal shedding of polyomavirus, single stool specimens from healthy adults were evaluated by PCR. Overall, 20 (18.2%) of 110 specimens were positive for human polyomaviruses: 9 with BKV, 9 with JC virus (JCV), 1 with SV40, and 1 with both JCV and SV40. Among the 94 subjects without immune compromise, 17 (18.1%) were excreting polyomaviruses. This shedding frequency in adults was significantly lower than that observed in children ( P < 0.001). These findings support the hypothesis that the gastrointestinal tract may be a site of polyomavirus persistence, and they suggest a fecal-oral route of viral transmission.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.02472-08

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