Detection of JC Virus in Cerebrospinal Fluid (CSF) Samples from Patients with Progressive Multifocal Leukoencephalopathy but Not in CSF Samples from Patients with Herpes Simplex Encephalitis, Enteroviral Meningitis, or Multiple Sclerosis

Author:

Bogdanovic G.1,Priftakis P.1,Hammarin A.-L.2,Söderström M.3,Samuelson A.1,Lewensohn-Fuchs I.1,Dalianis T.1

Affiliation:

1. Division of Clinical Virology, Department of Immunology, Microbiology, Pathology, and Infectious Diseases,1 and

2. Department of Virology, Swedish Institute for Infectious Disease Control, Stockholm,2 Sweden

3. Department of Ophthalmology and Neurology,3 Karolinska Institute, Huddinge University Hospital, Huddinge, and

Abstract

ABSTRACT JC virus (JCV) DNA was detected in cerebrospinal fluid (CSF) samples from patients with progressive multifocal leukoencephalopathy (PML) but not in CSF samples from patients with herpes simplex encephalitis, enteroviral meningitis, or multiple sclerosis. This suggests that inflammatory processes in the brain do not necessarily reactivate JCV, which further supports the proposal that the presence of JCV DNA in the CSF is diagnostic for PML.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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