Diagnostic value of detecting JC virus DNA in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy

Author:

Fong I W1,Britton C B1,Luinstra K E1,Toma E1,Mahony J B1

Affiliation:

1. Department of Medicine, St. Michael's Hospital, University of Toronto, Ontario, Canada.

Abstract

JC virus DNA was detected by PCR in the cerebrospinal fluid of 17 of 23 (73.9%) patients with confirmed cases of progressive multifocal leukoencephalopathy and 2 of 48 (4.2%) controls without progressive multifocal leukoencephalopathy. The sensitivity and specificity of this PCR were 74 and 95.8%, respectively, while the positive and negative predictive values were 89.5 and 88.5%, respectively.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference17 articles.

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