Immune response to dimeric subunits of the pertussis toxin B oligomer-Reference-Cited by-同舟云学术

Immune response to dimeric subunits of the pertussis toxin B oligomer

Published:1989-06 Issue:6 Volume:57 Page:1760-1764
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Hausman S Z¹,Burns D L¹,Sickler V C¹,Manclark C R¹

Affiliation:

1. Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892.

Abstract

Immunization of mice with the dimeric subunits of pertussis toxin (S2-S4 and S3-S4) induced an antibody response detectable by enzyme-linked immunosorbent assay and immunoblot techniques. These antibodies were able to neutralize the ability of pertussis toxin to alter the morphology of Chinese hamster ovary cells. Mice immunized with the dimers were also protected against the leukocytosis-promoting effects of toxin. Based on these data, the dimers of pertussis toxin may be considered for further study as potential vaccine candidates.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.57.6.1760-1764.1989

Reference32 articles.

1. Ad Hoc Group for the Study of Pertussis Vaccines. 1988. Placebocontrolled trial of two acellular pertussis vaccines in Swedenprotective efficacy and adverse events. Lancet i:955-960.

2. Immune response to the B oligomer of pertussis toxin;Arciniega J. L.;Infect. Immun.,1987

3. A rapid and sensitive method for quantitation of microgram quantities of protein using the principal of protein-dye binding;Bradford M. M.;Anal. Biochem.,1976

4. Western blotting;Burnette W. N.;Anal. Biochem.,1981

5. Direct expression of Bordetella pertussis toxin subunits to high levels in Escherichia coli;Burnette W. N.;Bio/Technology,1988

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Mechanistic Insight into Pertussis Toxin and Lectin Signaling Using T Cells Engineered To Express a CD8α/CD3ζ Chimeric Receptor;Biochemistry;2012-05-10

2. The New Generation of Recombinant Pertussis Vaccines;Modern Vaccinology;1994

3. Identification of B-cell epitopes on the S4 subunit of pertussis toxin;Infection and Immunity;1993-06

4. Identification of murine T-cell epitopes on the S4 subunit of pertussis toxin;Infection and Immunity;1993-01

5. Identification of human T-cell epitopes on the S4 subunit of pertussis toxin;Infection and Immunity;1992-10