Affiliation:
1. Department of Bacteriology, University of Bristol, University Walk, Bristol BS8 1TH, England
Abstract
The plasmid RP1 was shown to contain a genetic region (the
irp
region) responsible for influencing the intrinsic resistance of
Escherichia coli
to penicillins but not to cephalosporins. Mutants in which the
irp
genes are inactive were isolated. RP1 carrying functional
irp
genes protected
E. coli
AS19 against lysozyme lysis and also enhanced resistance to actinomycin D, to nalidixic acid, and to rifampin. This plasmid also phenotypically repaired the hypersensitivity to penicillins of strain AS19, and also that of
E. coli envA
mutants. Similar regions were not detected on the plasmids R1 and R55.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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