Affiliation:
1. Department of Bacteriology, The Medical School, University Walk, Bristol BS8 1TD, England
Abstract
RP1, a group of genes specifying resistance to carbenicillin, neomycin, kanamycin, and tetracycline and originating in a strain of
Pseudomonas aeruginosa
, was freely transmissible between strains of
P. aeruginosa, Escherichia coli
, and
Proteus mirabilis
. Acquisition of the multiple drug resistance specified by RP1 by these strains was accompanied by acquisition of an extrachromosomal satellite of covalently closed circular deoxyribonucleic acid of molecular weight about 40 million daltons and of buoyant density 1.719 g/cm
3
(60% guanine plus cytosine).
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
237 articles.
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