Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State-Reference-Cited by-同舟云学术

Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Zhang Peng¹,Kwon Alice L.¹,Guzzo Christina¹,Liu Qingbo¹,Schmeisser Hana¹,Miao Huiyi¹,Lin Yin¹,Cimbro Raffaello²,Huang Jinghe¹,Connors Mark¹,Schmidt Stephen D.³,Dolan Michael A.⁴,Armstrong Anthony A.⁴,Lusso Paolo¹^ORCID

Affiliation:

1. Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA

2. Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

3. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA

4. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA

Abstract

Elucidating the structure and function of the HIV-1 outer envelope proteins is critical for the design of an effective vaccine. Despite the availability of many high-resolution structures, key functional correlates in the envelope trimer remain undefined.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00090-21

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