Coevolutionary Analysis Implicates Toll-Like Receptor 9 in Papillomavirus Restriction

Author:

King Kelly1ORCID,Larsen Brendan B.2ORCID,Gryseels Sophie234ORCID,Richet Cécile5,Kraberger Simona5ORCID,Jackson Robert1ORCID,Worobey Michael26ORCID,Harrison Joseph S.7ORCID,Varsani Arvind58ORCID,Van Doorslaer Koenraad1691011ORCID

Affiliation:

1. School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona, USA

2. Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, USA

3. Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

4. Department of Biology, University of Antwerp, Antwerp, Belgium

5. The Biodesign Center for Fundamental and Applied Microbiomics, Center for Evolution and Medicine, School of Life Sciences, Arizona State University, Tempe, Arizona, USA

6. The BIO5 Institute, University of Arizona, Tucson, Arizona, USA

7. Department of Chemistry, University of the Pacific, Stockton, California, USA

8. Structural Biology Research Unit, Department of Integrative Biomedical Sciences, University of Cape Town, Observatory, Cape Town, South Africa

9. Department of Immunobiology, University of Arizona Tucson, Arizona, USA

10. Cancer Biology Graduate Interdisciplinary Program, University of Arizona Tucson, Arizona, USA

11. UA Cancer Center, University of Arizona Tucson, Arizona, USA

Abstract

Viruses must avoid detection by the innate immune system. In this study, we characterized two new papillomaviruses from bats and used molecular archeology to demonstrate that their genomes altered their nucleotide compositions to avoid detection by TLR9, providing evidence that TLR9 acts as a PRR during papillomavirus infection.

Funder

TRIF funding

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Cited by 8 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3