Effects of phosphonylmethoxyalkyl derivatives studied with a murine model for abortion induced by equine herpesvirus 1-Reference-Cited by-同舟云学术

Effects of phosphonylmethoxyalkyl derivatives studied with a murine model for abortion induced by equine herpesvirus 1

Published:1993-11 Issue:11 Volume:37 Page:2478-2482
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Awan A R¹,Field H J¹

Affiliation:

1. Department of Clinical Veterinary Medicine, Cambridge University, United Kingdom.

Abstract

(S)-9-(3-Hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) were tested in a mouse model for equine herpesvirus 1-induced abortion. HPMPA, given twice daily, reduced virus replication, but the compound was embryotoxic. A single dose of HPMPC, however, reduced the incidence of abortion and transfer of virus to the fetuses while producing no obvious toxic effects.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.37.11.2478

Reference29 articles.

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4. .Awan A. R. Unpublished data.

5. Awan A. R. Y.-C. Chong and H. J. Field. 1990. The pathogenesis of equine herpesvirus-1 in the mouse-a new model for 2482 NOTES

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