Affiliation:
1. ICN Pharmaceuticals, Inc., Nucleic Acid Research Institute, Irvine, California 92664
Abstract
Equine abortion virus (EAV)-induced hepatitis in hamsters presents an interesting animal model for the evaluation of drugs possessing anti-deoxyribonucleic acid virus activity. These experiments demonstrate that 9-β-
d
-arabinofuranosylhypoxanthine 5′-monophosphate (ara-HxMP), a new synthetic, water-soluble, antiviral agent, effectively controls this disease in hamsters with a therapeutic index of ∼60. Ara-HxMP prevented hepatitis-associated deaths in hamsters, reduced the titer of EAV developing in hamsters, and inhibited the increase of serum glutamic pyruvic transaminase in EAV-infected hamsters.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference8 articles.
1. Propagation of equine abortion virus in Syrian hamsters;Doll E. R.;Cornell Vet.,1956
2. Recent developments in viral hepatitis therapy;Hollander D.;Geriatrics,1973
3. Effect of antiviral agents in equine abortion virus-infected hamsters;Lieberman M.;Antimicrob. Agents Chemother.,1972
4. Studies on hepatitis in hamsters infected with equine abortion virus. I. Sequential development of inclusions and the growth cycle;Randall C. C.;Am. J. Pathol.,1957
5. Synthesis and antiviral activity of certain 5'-monophosphates of 9-i>arabinofuranosyladenine and 9-D-arabinofuranosylhypoxanthine;Revankar G. R.;J. Med. Chem.,1975
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