Mycobacterium avium strains resistant to clarithromycin and azithromycin-Reference-Cited by-同舟云学术

Mycobacterium avium strains resistant to clarithromycin and azithromycin

Published:1993-11 Issue:11 Volume:37 Page:2364-2370
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Heifets L¹,Mor N¹,Vanderkolk J¹

Affiliation:

1. National Jewish Center for Immunology, and Respiratory Medicine, University of Colorado Health Sciences Center, Denver.

Abstract

Mycobacterium avium strains susceptible to clarithromycin and azithromycin contain mutants resistant to these macrolides with a frequency of 1.1 x 10(-10) to 1.2 x 10(-6). Cross-resistance between clarithromycin and azithromycin was demonstrated with mutants selected in the laboratory as well as with resistant strains isolated from patients. The susceptibility-resistance patterns of the macrolide-resistant strains with drugs other than macrolides were the same as those of the original susceptible strains. The emergence of clarithromycin resistance in patients was a result of multiplication of the preexisting resistant mutants that survived the elimination of bacteria during the initial period of treatment and was an exclusive cause of the relapse of bacteremia.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.37.11.2364

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