<i>In Vitro</i> Resistance against DNA Gyrase Inhibitor SPR719 in Mycobacterium avium and Mycobacterium abscessus-Reference-Cited by-同舟云学术

In Vitro Resistance against DNA Gyrase Inhibitor SPR719 in Mycobacterium avium and Mycobacterium abscessus

Published:2022-02-23 Issue:1 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Aragaw Wassihun Wedajo¹,Cotroneo Nicole²^ORCID,Stokes Suzanne²,Pucci Michael²,Critchley Ian²,Gengenbacher Martin¹³^ORCID,Dick Thomas¹³⁴^ORCID

Affiliation:

1. Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA

2. Spero Therapeutics, Cambridge, Massachusetts, USA

3. Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA

4. Department of Microbiology and Immunology, Georgetown University, Washington, DC, USA

Abstract

Clinical emergence of resistance to new antibiotics affects their utility. Characterization of in vitro resistance is a first step in the profiling of resistance properties of novel drug candidates.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01321-21

Reference28 articles.

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3. NTM drug discovery: status, gaps and the way forward

4. DNA topoisomerase I and DNA gyrase as targets for TB therapy

5. Mutations in gyrA and gyrB in Moxifloxacin-Resistant Mycobacterium avium Complex and Mycobacterium abscessus Complex Clinical Isolates

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