Measurements of 5,6-Orthoquinone, a Surrogate for the Presumed Active Primaquine Metabolite 5-Hydroxyprimaquine, in the Urine of Cambodian Adults-Reference-Cited by-同舟云学术

Measurements of 5,6-Orthoquinone, a Surrogate for the Presumed Active Primaquine Metabolite 5-Hydroxyprimaquine, in the Urine of Cambodian Adults

Published:2022-03-15 Issue:3 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Vanachayangkul Pattaraporn¹,Sea Darapiseth²,Wojnarski Mariusz¹^ORCID,Sok Somethy²,Kodchakorn Chanikarn¹,Ta-aksorn Winita¹,Hom Sohei²,Ittiverakul Mali¹,Kuntawunginn Worachet¹,Arsanok Montri¹,Buathong Nillawan¹,Heng Thay Kheang²,Nareth Kong²,Nou Samon²,Chandara Sok²,Ly Sokna²,Oung Pheaktra²,Vesely Brian¹,Bennett Jason³,Reichard Gregory³,Pybus Brandon³,Lanteri Charlotte³,Saunders David⁴,Fukuda Mark¹,Smith Philip³,Dysoley Lek⁵,Rekol Huy⁵,Waters Norman C.¹,Spring Michele¹⁶^ORCID

Affiliation:

1. US Army Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand

2. US Army Armed Forces Research Institute of Medical Sciences, Phnom Penh, Cambodia

3. Walter Reed Army Institute of Research, Silver Spring, Maryland, USA

4. Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

5. National Malaria Program of Cambodia, Phnom Penh, Cambodia

6. The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA

Abstract

The active metabolites of primaquine, in particular 5-hydroxyprimaquine, likely responsible for the clearance of dormant hypnozoites, are produced through the hepatic CYP450 2D6 (CYP2D6) enzymatic pathway. With the inherent instability of 5-hydroxyprimaquine, a stable surrogate, 5,6-orthoquinone, can now be detected and measured in the urine as part of primaquine pharmacokinetic studies.

Funder

DOD | Defense Health Agency

U.S. Department of Defense

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01821-21

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5. Differential CYP 2D6 Metabolism Alters Primaquine Pharmacokinetics

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