CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine

Author:

Pybus Brandon S,Sousa Jason C,Jin Xiannu,Ferguson James A,Christian Robert E,Barnhart Rebecca,Vuong Chau,Sciotti Richard J,Reichard Gregory A,Kozar Michael P,Walker Larry A,Ohrt Colin,Melendez Victor

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases,Parasitology

Reference19 articles.

1. WHO: World Malaria Report 2011. 2011, World Health Organization, Geneva

2. Guerra CA, Snow RW, Hay SI: Mapping the global extent of malaria in 2005. Trends Parasitol. 2006, 22: 353-358. 10.1016/j.pt.2006.06.006.

3. Price RN, Tjitra E, Guerra CA, Yeung S, White NJ, Anstey NM: Vivax malaria: neglected and not benign. AmJTrop Med Hyg. 2007, 77: 79-87.

4. Bolchoz LJ, Budinsky RA, McMillan DC, Jollow DJ: Primaquine-induced hemolytic anemia: formation and hemotoxicity of the arylhydroxylamine metabolite 6-methoxy-8-hydroxylaminoquinoline. J Pharmacol Exp Ther. 2001, 297: 509-515.

5. Vasquez-Vivar J, Augusto O: Hydroxylated metabolites of the antimalarial drug primaquine. JBC. 1992, 267: 6848-6854.

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