Zinc Eluted from Siliconized Latex Urinary Catheters Decreases OprD Expression, Causing Carbapenem Resistance in Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Zinc Eluted from Siliconized Latex Urinary Catheters Decreases OprD Expression, Causing Carbapenem Resistance in Pseudomonas aeruginosa

Published:2003-07 Issue:7 Volume:47 Page:2313-2315
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Conejo M. Carmen¹,García Isabel¹,Martínez-Martínez Luis¹,Picabea Leandro²,Pascual Álvaro¹

Affiliation:

1. Department of Microbiology, School of Medicine, University of Seville

2. Forensic Science Institute, Seville, Spain

Abstract

ABSTRACT The activities of carbapenems against Pseudomonas aeruginosa decreased in the presence of siliconized latex urinary catheters (SLUCs). This effect was associated with the loss of OprD. The zinc that eluted from SLUCs is responsible for this phenomenon. We have found that zinc exerts a negative effect on the expression of OprD, the porin responsible for carbapenem entry into P. aeruginosa .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.7.2313-2315.2003

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