Emergence of Macrolide Resistance in Throat Culture Isolates of Group A Streptococci in Ontario, Canada, in 2001

Author:

Katz Kevin C.12,McGeer Allison J.12,Duncan Carla L.1,Ashi-Sulaiman Aisha1,Willey Barbara M.1,Sarabia Alicia3,McCann Jacquie3,Pong-Porter Sylvia1,Rzayev Yana1,de Azavedo Joyce S.12,Low Donald E.12

Affiliation:

1. Toronto Medical Laboratories/Mount Sinai Hospital Department of Microbiology

2. University of Toronto

3. MDS Laboratories, Toronto, Ontario, Canada

Abstract

ABSTRACT Of 500 group A streptococci isolated from pharyngeal swabs, 72 (14.4%) were macrolide resistant, compared to 2.1% in 1997. Of these, 66 (92%) were of the M phenotype and 6 (8.3%) were of the MLS phenotype. Pulsed-field gel electrophoresis found that two clones, with patterns identical to those of serotypes M1 and M4, accounted for 19.4 and 68.1% of the macrolide-resistant isolates, respectively.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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