Population Genomic Molecular Epidemiological Study of Macrolide-Resistant Streptococcus pyogenes in Iceland, 1995 to 2016: Identification of a Large Clonal Population with a pbp2x Mutation Conferring Reduced In Vitro β-Lactam Susceptibility-Reference-Cited by-同舟云学术

Population Genomic Molecular Epidemiological Study of Macrolide-Resistant Streptococcus pyogenes in Iceland, 1995 to 2016: Identification of a Large Clonal Population with a pbp2x Mutation Conferring Reduced In Vitro β-Lactam Susceptibility

Published:2020-08-24 Issue:9 Volume:58 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Southon Sara B.¹,Beres Stephen B.²^ORCID,Kachroo Priyanka²^ORCID,Saavedra Matthew Ojeda²,Erlendsdóttir Helga¹³,Haraldsson Gunnsteinn¹³^ORCID,Yerramilli Prasanti²,Pruitt Layne²,Zhu Luchang²,Musser James M.²⁴⁵,Kristinsson Karl G.¹³

Affiliation:

1. Department of Clinical Microbiology, Landspitali—The National University Hospital of Iceland, Reykjavik, Iceland

2. Center for Molecular and Translational Human Infectious Disease Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, USA

3. Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland

4. Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA

5. Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA

Abstract

Resistance to macrolide antibiotics is a global concern in the treatment of Streptococcus pyogenes (group A Streptococcus [GAS]) infections. In Iceland, since the detection of the first macrolide-resistant isolate in 1998, three epidemic waves of macrolide-resistant GAS infections have occurred, with peaks in 1999, 2004, and 2008. We conducted whole-genome sequencing of all 1,575 available GAS macrolide-resistant clinical isolates of all infection types collected at the national reference laboratory in Reykjavik, Iceland, from 1998 to 2016.

Funder

HHS | National Institutes of Health

Fondren Foundation

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00638-20

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