Histopathological Diagnosis of Prosthetic Joint Infection: Does a Threshold of 23 Neutrophils Do Better than Classification of the Periprosthetic Membrane in a Prospective Multicenter Study?

Author:

Bémer Pascale1,Léger Julie23,Milin Serge4,Plouzeau Chloé5,Valentin Anne Sophie6,Stock Nathalie7,Jolivet-Gougeon Anne8,Moreau Anne9,Corvec Stéphane1ORCID,Quintin-Roue Isabelle10,Tandé Didier11,Héry-Arnaud Geneviève11,Rousselet Marie-Christine12,Lemarié Carole13,Kempf Marie13,Michenet Patrick14,Bret Laurent15,de Pinieux Gonzague16,Burucoa Christophe5,

Affiliation:

1. Department of Bacteriology, Nantes University Hospital, Nantes, France

2. Inserm, CIC 1415, Tours, France

3. Tours University Hospital, Tours, France

4. Department of Anatomopathology, Poitiers University Hospital, Poitiers, France

5. Department of Bacteriology, Poitiers University Hospital, Poitiers, France

6. Department of Bacteriology, Tours University Hospital, Tours, France

7. Department of Anatomopathology, Rennes University Hospital, Rennes, France

8. Department of Bacteriology, Rennes University Hospital, Rennes, France

9. Department of Anatomopathology, Nantes University Hospital, Nantes, France

10. Department of Anatomopathology, Brest University Hospital, Brest, France

11. Department of Bacteriology, Brest University Hospital, Brest, France

12. Department of Anatomopathology, Angers University Hospital, Angers, France

13. Department of Bacteriology, Angers University Hospital, Angers, France

14. Department of Anatomopathology, Orléans Hospital, Orléans, France

15. Department of Bacteriology, Orléans Hospital, Orléans, France

16. Department of Anatomopathology, Tours University Hospital, Tours, France

Abstract

No gold standard exists for histopathological diagnosis of a prosthetic joint infection (PJI). The historical criterion considers the presence of neutrophil infiltration upon examination of periprosthetic tissue.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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