Affiliation:
1. Laboratories of Applied Microbiology, Faculty of Agriculture, Kagoshima University, Kagoshima, Japan
2. Department of Microbiology, The University of Texas, Austin, Texas
Abstract
Kanie, Matuso
(Kagoshima University, Kagoshima, Japan),
Shigeo Fujimoto, and J. W. Foster
. Chemical degradation of dipicolinic acid-
C
14
and its application to biosynthesis by
Penicillium citreo-viride
. J. Bacteriol.
91:
570–577. 1966.—A chemical degradation of dipicolinic acid-
C
14
has been worked out, enabling determination of the specific radioactivity of the carboxyl-carbons (carbons-7 and -8), and of the following carbons of the pyridine ring: carbons-2 and -6 combined, carbons-3 and -5 combined, and carbon-4. The degradation was applied to dipicolinic acid synthesized by washed, submerged mycelium of the mold from glucose and C
14
O
2
, and from glucose-
1-C
14
, -
2-C
14
, and -
6-C
14
. The distribution of radioactivity within the labeled dipicolinic acids is consistent with operation of respiratory cycles and with the incorporation of one molecule of CO
2
in the pyridine acid. A C
3
compound is a primary building block. The C
7
chain is believed to result from a C
3
plus C
4
condensation, pyruvic acid and aspartic acid β-semialdehyde being proposed as likely precursors. Other aspects of the biosynthesis of C
7
open-chain compounds and of dipicolinic acid are discussed.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
8 articles.
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