Affiliation:
1. Departments of Pathology
2. Epidemiology
3. Medicine, University of Iowa College of Medicine and College of Public Health, Iowa City, Iowa 52242
Abstract
ABSTRACT
Anidulafungin is an echinocandin antifungal agent with potent activity against
Candida
spp. We assessed the in vitro activity of anidulafungin against 2,235 clinical isolates of
Candida
spp. using the CLSI broth microdilution method. Anidulafungin was very active against
Candida
spp. (the MIC at which 90% of strains are inhibited [MIC
90
] was 2 μg/ml when MIC endpoint criteria of partial inhibition [MIC-2] were used).
Candida albicans
,
C. glabrata
,
C. tropicalis
,
C. krusei
, and
C. kefyr
were the most susceptible species of
Candida
(MIC
90
, 0.06 to 0.12 μg/ml), and
C. parapsilosis
,
C. lusitaniae
, and
C. guilliermondii
were the least susceptible (MIC
90
, 0.5 to 2 μg/ml). In addition, 315 fluconazole-resistant isolates were tested, and 99% were inhibited by ≤1 μg/ml of anidulafungin. These results provide further evidence for the spectrum and potency of anidulafungin activity against a large and geographically diverse collection of clinically important isolates of
Candida
spp.
Publisher
American Society for Microbiology
Cited by
145 articles.
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