Affiliation:
1. College of Pharmacy, The University of Iowa, Department of Pathology, The University of Iowa College of Medicine, Iowa City, Iowa 52242
Abstract
ABSTRACT
The postantifungal effect (PAFE) of fluconazole, MK-0991, LY303366, and amphotericin B was determined against isolates of
Candida albicans
and
Cryptococcus neoformans
. Concentrations ranging from 0.125 to 4 times the MIC were tested following exposure to the antifungal for 0.25 to 1 h. Combinations of azole and echinocandin antifungals (MK-0991 and LY303366) were tested against
C. neoformans
. Fluconazole displayed no measurable PAFE against
Candida albicans
or
Cryptococcus neoformans
, either alone or in combination with either echinocandin antifungal. MK-0991, LY303366, and amphotericin B displayed a prolonged PAFE of greater than 12 h against
Candida
spp. when tested at concentrations above the MIC for the organism and 0 to 2 h when tested at concentrations below the MIC for the organism.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
164 articles.
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