Caspases Switch off the m 6 A RNA Modification Pathway to Foster the Replication of a Ubiquitous Human Tumor Virus-Reference-Cited by-同舟云学术

Caspases Switch off the m 6 A RNA Modification Pathway to Foster the Replication of a Ubiquitous Human Tumor Virus

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Zhang Kun¹²,Zhang Yucheng³,Maharjan Yunash¹²,Sugiokto Febri Gunawan¹²,Wan Jun³⁴⁵^ORCID,Li Renfeng¹²⁶⁷^ORCID

Affiliation:

1. Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Richmond, Virginia, USA

2. Department of Oral and Craniofacial Molecular Biology, School of Dentistry, Virginia Commonwealth University, Richmond, Virginia, USA

3. Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA

4. Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, USA

5. Department of BioHealth Informatics, School of Informatics and Computing, Indiana University–Purdue University at Indianapolis, Indianapolis, Indiana, USA

6. Department of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA

7. Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA

Abstract

The discovery of an N 6 -methyladenosine (m 6 A) RNA modification pathway has fundamentally altered our understanding of the central dogma of molecular biology. This pathway is controlled by methyltransferases (writers), demethylases (erasers), and specific m 6 A binding proteins (readers).

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

American Cancer Society

National Cancer Institute

Virginia Commonwealth University

HHS | NIH | National Cancer Institute

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01706-21