Link between Heterotrophic Carbon Fixation and Virulence in the Porcine Lung Pathogen Actinobacillus pleuropneumoniae-Reference-Cited by-同舟云学术

Link between Heterotrophic Carbon Fixation and Virulence in the Porcine Lung Pathogen Actinobacillus pleuropneumoniae

Published:2019-09 Issue:9 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Konze Sarah A.¹,Abraham Wolf-Rainer²,Goethe Elke³,Surges Esther²,Kuypers Marcel M. M.⁴,Hoeltig Doris⁵,Meens Jochen³,Vogel Charlotte⁶,Stiesch Meike⁷,Valentin-Weigand Peter³,Gerlach Gerald-F.³,Buettner Falk F. R.¹^ORCID

Affiliation:

1. Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany

2. Helmholtz Center for Infection Research, Chemical Microbiology, Braunschweig, Germany

3. Institute for Microbiology, Department of Infectious Diseases, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany

4. Department of Biogeochemistry, Max Planck Institute for Marine Microbiology, Bremen, Germany

5. Clinic for Swine and Small Ruminants and Forensic Medicine and Ambulatory Services, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany

6. Department of Biometry, Epidemiology and Information Processing, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany

7. Department of Prosthetic Dentistry and Materials Sciences, Hannover Medical School, Hannover, Germany

Abstract

Actinobacillus pleuropneumoniae is a capnophilic pathogen of the porcine respiratory tract lacking enzymes of the oxidative branch of the tricarboxylic acid (TCA) cycle. We previously claimed that A. pleuropneumoniae instead uses the reductive branch in order to generate energy and metabolites. Here, we show that bicarbonate and oxaloacetate supported anaerobic growth of A. pleuropneumoniae .

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00768-18

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