The Metabolic Adaptation in Response to Nitrate Is Critical for Actinobacillus pleuropneumoniae Growth and Pathogenicity under the Regulation of NarQ/P-Reference-Cited by-同舟云学术

The Metabolic Adaptation in Response to Nitrate Is Critical for Actinobacillus pleuropneumoniae Growth and Pathogenicity under the Regulation of NarQ/P

Published:2022-09-15 Issue:9 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Zhang Qiuhong¹²,Tang Hao¹²,Yan Chaoyue¹²,Han Weiyao¹²,Peng Lu¹²,Xu Jiajia¹²,Chen Xiabing³,Langford Paul R.⁴^ORCID,Bei Weicheng¹²^ORCID,Huang Qi¹²⁵,Zhou Rui¹²⁵^ORCID,Li Lu¹²⁵^ORCID

Affiliation:

1. State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China

2. Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, Hubei, China

3. Institute of Animal Husbandry and Veterinary Science, Wuhan Academy of Agricultural Sciences, Wuhan, Hubei, China

4. Section of Paediatric Infectious Disease, Imperial College London, St Mary’s Campus, London, United Kingdom

5. International Research Center for Animal Disease, Ministry of Science and Technology of the People’s Republic of China, Wuhan, Hubei, China

Abstract

Nitrate metabolism is an adaptation mechanism used by many bacteria for survival in anaerobic environments. As a by-product of inflammation, nitrate is used by the intestinal bacterial pathogens to enable gut infection.

Funder

Department of Science and Technology, Hubei Province | Hubei Provincial Central Guidance Local Science and Technology Development Project

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

UKRI | Biotechnology and Biological Sciences Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00239-22

Reference72 articles.