Nef Enhances Human Immunodeficiency Virus Type 1 Infectivity and Replication Independently of Viral Coreceptor Tropism-Reference-Cited by-同舟云学术

Nef Enhances Human Immunodeficiency Virus Type 1 Infectivity and Replication Independently of Viral Coreceptor Tropism

Published:2002-08-15 Issue:16 Volume:76 Page:8455-8459
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Papkalla Armin¹,Münch Jan²,Otto Claas²,Kirchhoff Frank²

Affiliation:

1. Institute for Clinical and Molecular Virology, University of Erlangen-Nürnberg, 91054 Erlangen

2. Department of Virology, University of Ulm, 89081 Ulm, Germany

Abstract

ABSTRACT We investigated the infectivities and replicative capacities of a large panel of variants of the molecular human immunodeficiency virus type 1 (HIV-1) NL4-3 clone that differ exclusively in the V3 region of the viral envelope glycoprotein and the nef gene. Our results demonstrate that Nef enhances virion infectivity and HIV-1 replication independently of the viral coreceptor tropism.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.76.16.8455-8459.2002

Reference46 articles.

1. Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A

2. Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis

3. A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 nef alleles in lymphocyte activation

4. CHEMOKINE RECEPTORS AS HIV-1 CORECEPTORS: Roles in Viral Entry, Tropism, and Disease

5. Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease

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