Emergence of Ceftriaxone Resistance during a Case of Pneumococcal Meningitis with Fatal Evolution-Reference-Cited by-同舟云学术

Emergence of Ceftriaxone Resistance during a Case of Pneumococcal Meningitis with Fatal Evolution

Published:2020-02-21 Issue:3 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Mizrahi A.¹²^ORCID,Marvaud J. C.²^ORCID,Pilmis B.²³,Nguyen Van J. C.¹,Couzigou C.³,Bruel C.⁴,Engrand N.⁵,Le Monnier A.¹²,Lambert T.¹²

Affiliation:

1. Laboratoire de Microbiologie Clinique, Groupe Hospitalier Paris Saint-Joseph, Paris, France

2. EA 4043 Unité Bactéries Pathogènes et Santé, Université Paris-Saclay, Université Paris-Sud, Paris, France

3. Equipe Mobile de Microbiologie Clinique, Groupe Hospitalier Paris Saint-Joseph, Paris, France

4. Réanimation Polyvalente, Groupe Hospitalier Paris Saint-Joseph, Paris, France

5. Réanimation NeuroChirurgicale, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France

Abstract

We report a case of a 62-year-old man treated for Streptococcus pneumoniae meningitis by ceftriaxone and dexamethasone. After neurological improvement, neurological degradation by vasculitis occurred, despite effective concentrations of ceftriaxone in the serum and cerebrospinal fluid (CSF). S. pneumoniae with increased MICs to third-generation-cephalosporins (3GC) was isolated from the ventricular fluid 10 days after the isolation of the first strain. Isolate analysis showed that a mutation in the penicillin-binding protein 2X (PBP2X) has occurred under treatment.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01958-19

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